Richard L Proia Selected Research

Sphingolipids

12/2023	Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.
1/2023	Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
1/2021	Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease.
12/2019	Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.
12/2014	Autophagy regulates sphingolipid levels in the liver.
5/2014	Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
4/2010	Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
10/2007	Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.

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Richard L Proia Research Topics

Disease

9	Inflammation (Inflammations) 12/2023 - 05/2002
7	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2023 - 12/2004
5	Insulin Resistance 12/2023 - 03/2003
3	GM1 Gangliosidosis (Gangliosidosis GM1) 10/2023 - 12/2019
3	Atherosclerosis 12/2019 - 08/2015
3	Anaphylaxis (Anaphylactic Shock) 04/2018 - 03/2007
3	Sandhoff Disease (Sandhoff's Disease) 01/2018 - 06/2004
3	Neoplasms (Cancer) 11/2017 - 10/2002
3	Multiple Sclerosis 01/2016 - 05/2011
2	Asthma (Bronchial Asthma) 01/2023 - 11/2013
2	Brain Injuries (Brain Injury) 01/2021 - 05/2014
2	Thrombocytopenia (Thrombopenia) 11/2019 - 11/2012
2	Hemorrhage 11/2019 - 12/2005
2	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2018 - 06/2016
2	Vascular Diseases (Vascular Disease) 08/2015 - 10/2004
2	Neuroinflammatory Diseases 07/2015 - 04/2015
2	Hypoxia (Hypoxemia) 03/2015 - 04/2004
2	Gliosis 05/2011 - 08/2008
1	Lung Injury 01/2024
1	Hypertrophy 12/2023
1	Overnutrition 12/2023
1	Obesity 12/2023
1	Dyslipidemias (Dyslipidemia) 12/2023
1	Alcoholic Fatty Liver 12/2023
1	Fibrosis (Cirrhosis) 12/2023
1	Liver Cirrhosis (Hepatic Cirrhosis) 12/2023
1	Hyperinsulinism (Hyperinsulinemia) 12/2023
1	Disease Progression 10/2023
1	Retinal Neovascularization 10/2022
1	Corneal Injuries 01/2022
1	Burns 01/2022
1	Corneal Neovascularization 01/2022
1	Sphingolipidoses (Sphingolipidosis) 01/2021
1	Ischemic Stroke 01/2021
1	Hemorrhagic Stroke 01/2021
1	Nervous System Malformations (Nervous System Congenital Malformations) 03/2020
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 03/2020
1	Ischemia 01/2020
1	Coronary Disease (Coronary Heart Disease) 12/2019
1	Thrombosis (Thrombus) 11/2019
1	Macular Degeneration (Age-Related Maculopathy) 10/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2019
1	Lymphoma (Lymphomas) 11/2017
1	Fatty Liver 01/2017
1	Gangliosidoses (Gangliosidosis) 06/2016
1	Alzheimer Disease (Alzheimer's Disease) 01/2016
1	Hypersensitivity (Allergy) 01/2015

Drug/Important Bio-Agent (IBA)

13	Sphingosine-1-Phosphate ReceptorsIBA 01/2021 - 04/2004
8	SphingolipidsIBA 12/2023 - 10/2007
8	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2023 - 01/2015
8	sphingosine kinaseIBA 01/2022 - 08/2006
7	SphingosineIBA 12/2019 - 12/2004
6	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021 - 12/2004
6	LipidsIBA 12/2019 - 04/2010
5	EnzymesIBA 01/2021 - 05/2002
4	CeramidesIBA 12/2023 - 12/2014
3	GalactosidasesIBA 10/2023 - 12/2019
3	GlycosphingolipidsIBA 01/2023 - 12/2005
3	Proteins (Proteins, Gene)FDA Link 03/2020 - 12/2004
3	Phosphotransferases (Kinase)IBA 05/2010 - 08/2006
2	G(M1) GangliosideIBA 10/2023 - 12/2019
2	Immunoglobulin E (IgE)IBA 04/2018 - 11/2013
2	GangliosidesIBA 06/2016 - 10/2002
2	CytokinesIBA 11/2014 - 03/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2005 - 01/2005
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2024
1	SugarsIBA 12/2023
1	Glucose (Dextrose)FDA LinkGeneric 12/2023
1	Neuraminidase (Sialidase)IBA 10/2023
1	Protein Isoforms (Isoforms)IBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	SynucleinsIBA 01/2023
1	Serine C-PalmitoyltransferaseIBA 01/2023
1	Interleukin-17 (Interleukin 17)IBA 01/2023
1	Oxygen (Dioxygen)IBA 10/2022
1	AlkaliesIBA 01/2022
1	SphingomyelinsIBA 01/2022
1	Complement System Proteins (Complement)IBA 03/2020
1	Complement Inactivating AgentsIBA 03/2020
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2020
1	LigandsIBA 01/2020
1	Vasoconstrictor AgentsIBA 01/2020
1	CholesterolIBA 12/2019
1	LDL Receptors (LDL Receptor)IBA 08/2018
1	oxidized low density lipoproteinIBA 08/2018
1	anti-IgE antibodiesIBA 04/2018
1	IgE Receptors (Fc epsilon RI)IBA 04/2018
1	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2018
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2018
1	Hexosaminidase A (Hex A)IBA 01/2018
1	Cell Surface ReceptorsIBA 11/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2017
1	Blood Glucose (Blood Sugar)IBA 01/2017
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 08/2015
1	Apolipoproteins E (ApoE)IBA 08/2015
1	TRPC6 Cation ChannelIBA 03/2015
1	Interleukin-6 (Interleukin 6)IBA 11/2014

Therapy/Procedure

2	Therapeutics 11/2017 - 06/2016
1	Tissue Expansion 01/2018
1	Injections 01/2015